Need for clarification of data in a recent meta-analysis about TP53 codon 72 polymorphism and cancer susceptibility

Clarification of data for a meta-analysis: p53 codon 72 polymorphism and prostate cancer risk.

Association of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis

This study was conducted in order to investigate the implications of the R72P polymorphism in the TP53 gene in breast cancer risk. The enlightenment of this matter might provide a piece of information about the potential implications of this polymorphism in patient risk. A meta-analysis was conducted considering a large sample size from studies with conflicting results on the R72P polymorphism ...

Analysis of TP53 Codon 72 Polymorphism in Mucinous and Non-Mucinous Colorectal Adenocarcinoma in Isfahan, Iran

Background: The tumor suppressor gene TP53 (alias p53) located on chromosome 17 is involved in various cancers. Case-control studies have shown that p53 codon 72 polymorphism modulates the prognosis and susceptibility to various malignancies. We undertook the present study to explore a possible association between mucinous and non-mucinous adenocarcinomas with different genotypes or alleles at ...

TP53 codon 72 polymorphism and susceptibility to cervical cancer in the Chinese population: an update meta-analysis.

BACKGROUND Although many epidemiologic studies investigated the TP53 codon 72 polymorphism and its association with cervical cancer (CC), definite conclusions cannot be drawn. AIM OF THE STUDY To evaluate the association between TP53 codon 72 polymorphism and risk of cervical cancer in the Chinese population. METHODS A computerized literature search was carried out in PubMed, Springer Link,...

The Relations between EGFR R521K Polymorphism and Risk of Cancer: Need for Clarification of Data in a Recent Meta-Analysis

Recently we read with great interest the paper by Wang et al. [1]. The authors conducted a meta-analysis of 13 studies containing 7328 cases and 8455 controls to estimate the association of R521K polymorphism in EGFR gene with risk of cancer. This meta-analysis suggested that the EGFR R521K polymorphism is not associated with risk of cancer except a statistical difference between A and G allele...